The blocks that make up a file might be arranged contiguously on disk, and file system performance is generally better if they are, but most operating systems don’t require contiguous allocation. They are free to place a block anywhere on disk, and they use various data structures to keep track of them.
In many UNIX file systems, that data structure is called an “inode,” which stands for “index node”. More generally, information about files, including the location of their blocks, is called “metadata”. (The content of the file is data, so information about the file is data about data, hence “meta”.)
Since inodes reside on disk along with the rest of the data, they are designed to fit neatly into disk blocks. A UNIX inode contains information about a file, including the user ID of the file owner; permission flags indicating who is allowed to read, write, or execute it; and timestamps that indicate when it was last modified and accessed. In addition, it contains block numbers for the first 12 blocks that make up the file.
If the block size is 8 KiB, the first 12 blocks make up 96 KiB. On most systems, that’s big enough for a large majority of files, but it’s definitely not big enough for all of them. That’s why the inode also contains a pointer to an “indirection block”, which contains nothing but pointers to other blocks.
The number of pointers in an indirection block depends on the sizes of the blocks and the block numbers, but it is often 1024. With 1024 block numbers and 8 KiB blocks, an indirection block can address 8 MiB. That’s big enough for all but the largest files, but still not big enough for all.
That’s why the inode also contains a pointer to a “double indirection block”, which contains pointers to indirection blocks. With 1024 indirection blocks, we can address 8 GiB.
And if that’s not big enough, there is (finally) a triple indirection block, which contains pointers to double indirection blocks, yielding a maximum file size of 8 TiB. When UNIX inodes were designed, that seemed big enough to serve for a long time. But that was a long time ago.
As an alternative to indirection blocks, some files systems, like FAT, use a File Allocation Table that contains one entry for each block, called a “cluster” in this context. A root directory contains a pointer to the first cluster in each file. The FAT entry for each cluster points to the next cluster in the file, similar to a linked list. For more details, see http://en.Wikipedia.org/wiki/File_Allocation_Table.